Novartis claims first CAR-T approval, setting $475k price tag

01 September, 2017, 01:49 | Author: Garry Little
  • US clears first 'living drug' for childhood leukaemia

The U.S. Food and Drug Administration announced the approval Wednesday, weeks ahead of schedule.

The FDA-approved drug Kymriah has been called a "living drug" because involves using genetically modified immune cells from patients to attack their cancer, according to NPR. The first gene therapy to gain FDA approval for an inherited disease could be a treatment for a form of blindness.

Dr. Stephan Grupp from Children's Hospital in Philadelphia has already treated the first child with the CAR-T cell therapy.

"We're at the very beginning of what's going to be a big new field of medicine", David Epstein, who helped license Kymriah in from the University of Pennsylvania while at Novartis. The new cells would then continue to multiply to fight disease for months or years.

On Wednesday, the FDA also expanded approval for another drug, tocilizumab, to treat CRS in patients 2 and older.

The new treatment modifies patients' own immune T cells, which are collected and reprogrammed at the Novartis manufacturing facility to potentially seek and destroy the patients' leukemia cells.

However, this type of therapy carries risk of severe side effects. The T cells grow hundreds of millions of copies and fight back leukemia.

The drug has shown promising remission and survival rates in clinical trials, the FDA said.

It doesn't matter if Taylor's new song is any good
The song " Shake It Off ", from her 2014 album, "1989", particularly highlights this. She also overtook Adele's Hello as the most-watched video on day of release.

The therapy is called Kymriah, and it is being made by Norvartis.

The FDA's move to approve the vehicle T-cell therapy, which will be marketed under the name "Kymriah" by Novartis Pharmaceuticals, opens the door to a new era of cancer medicine, and medicine more broadly.

Despite Kymriah's success in the clinical trial, Walid Gellad, a doctor and professor at the University of Pittsburgh, suggested to Axios that treatments with undetermined effectiveness-even if they have the potential to save lives-shouldn't cost more than proven measures such as bone marrow or kidney transplants, adding: "This is an awesome therapy, but there has to be a limit at which point companies can no longer charge desperate patients, or taxpayers, enormous sums".

Kymriah does have side effects, causing cytokine release syndrome, a systemic response to the proliferation of vehicle T-cells that can cause flu-like symptoms such as a high fever, and neurological events.

Epstein said he envisions cell therapies having much shorter life cycles than traditional drugs. The company did say that it's made an agreement with the US government to pay for the drug only when pediatric or young adult patients with the cancer respond to treatment by the end of their first month. Instead of getting a better, updated therapy for a disease every decade or so, we might begin to see second-generation cell therapies in a few years. Researchers are trying to get the approach to work for solid tumors.

Since its founding in 2001, ACGT has allocated approximately $29 million in grants to US and Canadian cancer gene therapy research projects. "Through our collaboration with Novartis, we are creating the next wave of immunocellular cancer treatments, and are eager to progress CAR-T therapy in a host of haematologic and other cancer types".

Based on available data, patients on the treatment have had an 89% chance of surviving at least six months and a 79% chance of surviving at least a year, with most being relapse-free at that point.

Recommended:

  • West Nile-infected mosquitoes found in Groton

    West Nile-infected mosquitoes found in Groton

    Empty any unused flowerpots and wading pools, and change water in birdbaths frequently. Mild illness may include headache, body aches, joint pain, vomiting diarrhea, or rash.
    US Navy Shoots Down Medium-Range Missile Off Hawaii in Test

    US Navy Shoots Down Medium-Range Missile Off Hawaii in Test

    The ground-based interceptor system was designed mainly to counter a North Korean missile threat, a US official said at the time. The Pacific Missile Range Facility on Kauai launched the target missile late Tuesday.
    Spain hires more staff at drug agency to prepare for Brexit disruption

    Spain hires more staff at drug agency to prepare for Brexit disruption

    There will be two more rounds of negotiations in September and October before March 2019 when the Brexit deadline will be due. In December, EU member states agreed that no new accession chapters would be opened until Ankara reversed course.
  • Musharraf a fugitive in Bhutto case: court

    Musharraf a fugitive in Bhutto case: court

    The court has ordered to release Rafaqat, Husnain, Rasheed Ahmad, Sher Zaman and Aitzaz Shah immediately, news reports stated. She was killed when she stood up and put her head out of a sunroof-style escape hatch in the bombproof vehicle.
    Bolton: Here's how Trump can drop Iran deal

    Bolton: Here's how Trump can drop Iran deal

    Last week, Iranian President Hassan Rouhani threatened to quit the nuclear pact if the White House issues new sanctions.
    House Dems urge Trump to reconsider military transgender ban

    House Dems urge Trump to reconsider military transgender ban

    The White House had said that transgender people would be allowed to continue serving until Mattis had completed such an analysis. The US official added that for now, the current policy in respect to transgenders serving in the military remains in effect.
  • Brexit-wary Japan executives to talk with United Kingdom  trade chief

    Brexit-wary Japan executives to talk with United Kingdom trade chief

    Several Japanese financial institutions have chose to set up hubs in Frankfurt and Amsterdam to protect themselves from Brexit.
    North Korea's Ri Sol Ju gave birth to third child

    North Korea's Ri Sol Ju gave birth to third child

    In fact, Kim and Ri's marriage wasn't even confirmed until 2012, at which point they'd been married for roughly three years. She visited South Korea in 2005 as a cheerleader for her country's squad in the Asian Athletics Championships.
    President Donald Trump Goes On Road Trip To Sell Tax Reform Plan

    President Donald Trump Goes On Road Trip To Sell Tax Reform Plan

    He said it would provide tax relief for middle-class families, boost economic growth, and bring business back to the US. He called this a "once in a generation opportunity to deliver real tax reform for every day hard working Americans".
  • Sharapova battles into third round at US Open

    Sharapova battles into third round at US Open

    CiCi Bellis of the United States was serving for the match at 5-3 in the third set but lost to Nao Hibino of Japan 6-3, 4-6, 7-5. I knew she had a hard first match here so I used that as confidence. "I knew it was going to be a tough match from the get-go".
    Bangladesh Claim Historic Test Victory over Australia

    Bangladesh Claim Historic Test Victory over Australia

    We have been consistent in home conditions". "We had that confidence and the belief came from the last two to three years. Cummins and Ashton Agar stalled Bangladesh's progress to steer Australia to 193-8 at tea, combining 49 off 143.
    ISIL evacuation deal sparks Iraqi outrage

    ISIL evacuation deal sparks Iraqi outrage

    On Tuesday, the ISIS fighters reached in Deir al-Zour province in eastern Syria, near the border with Iraq. He praised the Lebanese army for carrying out the operation that ended with the ISIL deal.


Popular

With 100 miles per hour winds, Hurricane Irma gaining strength in Atlantic
The center of Irma is located about 720 miles to the west of the Cabo Verde Islands and is moving west-northwest at 10 to 15 mph. Kottlowski said lots of atmospheric factors will come into play during the next week to determine the path of Hurricane Irma .

At Least 18000 Rohingya Muslims Flee Myanmar for Bangladesh
The guards were also put on alert at various points of 271 kilometers of border that Bangladesh shares with Myanmar in the country's south-east.

Andy Murray will not be at Flushing Meadows
Open because of a hip injury, adding to the lengthy list of top players who will miss the year's last Grand Slam tournament. They were drawn Friday into the same half of the bracket, meaning they could only meet in the semifinals in NY .

At Long Last, Sean Spicer Gets to Meet Pope Francis
And many commentators said they felt bad for Spicer, who attends Mass regularly and would have been deeply moved to meet the Pope. Spicer, who is Catholic, was serving as US President Donald Trump's press secretary when Trump travelled to the Vatican in May.

Humane Society of Tulsa asking for donations for pets removed from Houston
On Sunday, the Harlingen Humane Society said they saved 36 animals from a shelter, which was destroyed by the storm. This isn't the first time PETA's rescue team has come to the aid of animals put at risk by a natural disaster.