But back in 2015 there was no data to show the drug actually reduced cardiovascular events, and the data from the FOURIER study, involving more than 27,000 patients, resolves this issue.
The drug, Repatha, is called a PCSK9 inhibitor and can make cholesterol tumble to levels nearly never seen naturally in adults, or even in people taking cholesterol-lowering statins.
"There has always been a debate that low LDL cholesterol levels could lead to negative effects on memory or other cognitive functions", saidRobert P. Giugliano, M.D., S.M., Brigham and Women's Hospital, Boston and lead study investigator. ( AMGN ) announced results from the Repatha or evolocumab cognitive function trial (EBBINGHAUS) evaluating the impact on cognitive function in 1,974 patients enrolled in the Repatha cardiovascular outcomes study, FOURIER.
Not necessarily, say analysts, who reckon TMC and Alnylam can learn from experiences with the established drugs for their phase 3 program, which is due to start mid-year, and set themselves up for success.
The results of a two-year clinical trial on the drug sold as Repatha by Amgen Phamaceuticals that costs more than $14,000 a year were released at the American College of Cardiology annual conference in the U.S. capital.
This made "a dramatic difference", even if the drug could save just two percent of patients' lives, said Kevin Marzo, chief of the division of cardiology at Winthrop-University Hospital in Mineola, New York, who was not involved in the study.
The British Heart Foundation said the findings were a significant advance in fighting the biggest killer in the world, with about 15 million people dying each year from heart attacks or stroke.
The two clinical trials were funded by the drugs' respective makers - Amgen for evolocumab and the Medicines Company/Alnylam Pharmaceuticals for inclisiran. But any new cholesterol drug faces stiff competition from cheaper statins, which have been used to control LDL levels for decades.
The study mainly revolves around the severe major adverse cardiovascular event (MACE), which refers to events like first heart attack, strokes or cardiovascular death. In clinical trials, both Repatha and its competitor, a drug called Praluent developed by Sanofi and Regeneron, reduced LDL cholesterol by about 60% in patients already taking statins. The rest of the patients, due to narrowed arteries, were suffering from pain in their legs and had a stroke.
The cost varies, but it is thought to cost the UK's NHS about £2,000 per year per patient where it is already being given to people who do not respond to statins.
Repatha costs about £4,400 per patient per year, although the NHS has agreed an undisclosed discount.
Safety-wise, Repatha patients didn't see some of the side effects that other lipid therapies produce, he said.
However, Prof Sever said: "They will probably not [replace statins], there are an terrible lot of people with really quite high cholesterol out there and we'll probably need more than one drug to get their levels down".
Sean Harper, executive vice president at Amgen, added: 'This is a game changer for high-risk patients'.
"It would be hard for me to look a patient in the eye, if they've had a couple of heart attacks and is scared to death, and say it's not worth you taking this medication", Nissen said. The fresh evidence could mean many more patients become eligible. A similar drug to Repatha, called Praluent, costs about as much.
The decline in Trump's net worth is due to a drop in the value of office space in Midtown Manhattan, according to the Guardian . Facebook founder Mark Zuckerberg moved up to number five for the first time, after his fortune rose $11.4 billion in 12 months.
He is another who has been playing in every game. "He told me if any of our players gets injured, the insurance paid". He was feeling something in the first half and in the second half he immediately felt he couldn't carry on.
Windows 7 is to receive security updates until January 14, 2020, while Windows 8.1's support is to end on January 10, 2023. It seems clear, though, that Microsoft doesn't want these processors to work on their older operating systems.
Holding her medal of the Member of the Order of the Companions of Honour at her home in Ditchling, East Sussex. Sir Patrick Stewart was among those paying tribute to Dame Vera, admitting that her music still makes him cry.
A spokeswoman for L'Oréal said the company was "unaware" and "horrified" that its ads were being placed on such YouTube channels. Britain is the second largest market for Google following the USA , generating $7.8 billion primarily from advertising in 2016.
No release date was announced and a rep for Berry and Berry's record label did not return Fox News' request for comment. Berry soon realized that he would have to play for multiracial audiences, as he was booked on segregated theaters.
And I don't expect them to get to this point and try to change up what they're doing. "And we just gotta be ready for it". These Razorbacks aren't pushing the pace to that extent, but they'll press, run and trap while mixing in zone looks, too.
Troops are now advancing towards the Mosul's grand mosque where the Islamic State declared a caliphate in 2014. An air strike targeting one Islamic State position hit a building, engulfing nearby troops in smoke and dust.
It is also America's seventh best debut of all time and the top March debut ever , despite controversy in some countries. In a sign of its popularity, Beauty and the Beast topped the box office in almost every market where it screened.
However, his efficiency did take a hit in the second half when he shot 1-9 from the field and failed to pick up another assist. I don't necessarily think when you get into the NCAA tournament and have one day of prep you switch everything you're doing.
Alli hit his 14th league goal of the season from the spot after being fouled by Steven Davis midway through the first half. The last time the Spurs suffered a loss at home was when Southampton visited the London side in May of previous year .
G-20 Drops Anti-Protectionist Language in Communique
Ironically, China and some European states tend to intervene more often in private-sector business than the US government. Trump and other critics of free trade argue that it can cause jobs to move to lower-cost countries.
Beauty And The Beast Breaks UK Box Office Records
The film will also hold the title for the most successful opening weekend for a PG film, musical and non-sequel. Per studio estimates, the live-action " Beauty " earned $170.0 million in its first weekend.
No. 2 seed Louisville faces MI in coaching rematch
The Wolverines advance to the round of 16 where they will face the victor of third-seeded OR and 11th-seeded Rhode Island. Senior Mangok Mathiang scored 13 points and grabbed four rebounds in the final game of his career.